Topology of Plasmin-Driven Fibrinolysis in a Nanoscale Fibrin Matrix
نویسندگان
چکیده
منابع مشابه
Early events in the plasmin digestion of fibrinogen and fibrin. Effects of plasmin on fibrin polymerization.
We have studied the effects of limited plasmic digestion of fibrinogen and fibrin on the physical properties of fibrin gels. After limited digestion the rigidity (elasticity) of the clot formed from degraded fibrinogen is 1% of the rigidity obtained from undegraded fibrinogen, whereas the decrease in clottability as a result of this limited digestion is only about 10%. When plasmin digests fibr...
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Fibrin fibers form the structural backbone of blood clots; fibrinolysis is the process in which plasmin digests fibrin fibers, effectively regulating the size and duration of a clot. To understand blood clot dissolution, the influence of clot structure and fiber properties must be separated from the effects of enzyme kinetics and perfusion rates into clots. Using an inverted optical microscope ...
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Active-site-inhibited plasmin was prepared by inhibition with d-valyl-l-phenylalanyl-l-lysylchloromethane or by bovine pancreatic trypsin inhibitor (Kunitz inhibitor). Active-site-inhibited Glu-plasmin binds far more strongly to fibrin than Glu-plasminogen [native human plasminogen with N-terminal glutamic acid (residues 1-790)]. This binding is decreased by alpha(2)-plasmin inhibitor and trane...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.1242